304passessment of Bisphosphonates Use as Adjuvant Therapy in Breast Cancer.
نویسندگان
چکیده
F.M. Abu-Taleb1, H.M. El-Zawahry2, Z.K. Zekri2, R.M.M. Gaafar2, N.M.A. Al Lahloubi2, N. Zakhari3, O. Elfarargy1, A. Abdel Raheem Alnagar1 Medical Oncology, Zagazig University Hospitals, Faculty of Medicine, Sharkia, EGYPT Medical Oncology, National Cancer Institute Kasr El AiniCairo University, Cairo, EGYPT Biochemistry and Tumour Biology, National Cancer Institute Kasr El AiniCairo University, Cairo, EGYPT
منابع مشابه
The role of bisphosphonates in the adjuvant setting for breast cancer.
Bone health is a critical issue in the management of women with breast cancer. Many women who develop breast cancer are postmenopausal, which already predisposes them to osteoporosis. Systemic treatments for breast cancer, including chemotherapy and endocrine therapy, decrease circulating levels of estrogen in both pre- and postmenopausal women, further accelerating the natural process of bone ...
متن کاملBisphosphonates and breast cancer incidence and recurrence.
Bisphosphonates are commonly used in patients with breast cancer to reduce skeletal-related events in metastatic disease and to mitigate bone loss associated with adjuvant therapy. Preclinical studies have shown that bisphosphonates may directly inhibit breast cancer cell proliferation and metastasis. Clinical trials evaluating the oral bisphosphonate clodronate as a component of adjuvant thera...
متن کاملThe use of adjuvant bisphophonates in the treatment of early-stage breast cancer.
Adjuvant treatment of breast cancer has resulted in significant improvement in breast cancer-related outcomes. In addition to chemotherapy and endocrine therapy, the bone-protective agents known as bisphosphonates have been extensively investigated for their putative antitumor effect. Backed by strong preclinical data from in vitro and in vivo models, several randomized clinical trials have eva...
متن کاملThe Frequency of and Risk Factors for the Use of Bisphosphonates in the Adjuvant Setting of Primary Breast Cancer in Germany
PURPOSE The aim of this cross-sectional health care study (use of bisphosphonates in primary tumors of the mammae, EBisMa) is to determine how often bisphosphonate medication is used in patients with non-metastatic primary breast cancer treatment, but who do not suffer from osteoporosis. Furthermore, we describe patients' characteristics and the most frequently used type of bisphosphonate in ad...
متن کاملUse of aromatase inhibitors and bisphosphonates as an anticancer therapy in postmenopausal breast cancer.
Breast cancer is a major cause of morbidity and mortality in postmenopausal women worldwide. Reducing the risk of distant disease recurrence is a primary goal of adjuvant endocrine therapy. As we await data from ongoing Phase III comparison trials, an emerging body of evidence demonstrates important differences between third-generation aromatase inhibitors, particularly with respect to potency ...
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ورودعنوان ژورنال:
- Annals of oncology : official journal of the European Society for Medical Oncology
دوره 25 suppl_4 شماره
صفحات -
تاریخ انتشار 2014